| 학회 |
한국재료학회 |
| 학술대회 |
2012년 가을 (11/07 ~ 11/09, 라카이샌드파인 리조트) |
| 권호 |
18권 2호 |
| 발표분야 |
D. 바이오재료(Biomaterials) |
| 제목 |
Mechanical Properties and in vitro Characterization of Hyaluronic Acid-Gelatin-Bioactive glass Composite for Tissue Regeneration |
| 초록 |
Composite scaffolds of homogeneously mixed hyaluronic acid (HA), gelatin (G) and bioactive glass (BG) incorporated with BMP2 were fabricated with variable component compositions of bioactive glass. The goals of this study were to analyze the mechanical properties of produced composite scaffolds as well as to assess the effects of adding BG to the composite scaffolds on attachment, proliferation, and chondrogenic differentiation of human adipose stem cells. In BG composite scaffolds, a significant amount of cartilage-specific extracellular matrix components was deposited as compared with HA/G scaffolds. Additionally, BG containing composite scaffolds displayed greater promotion of collagen type II expression than only HA/G scaffolds. The mechanism, based on which cell adhesion was influenced, was examined. In summary, the results describe the establishment of a class of composite polymer scaffolds, consisting of hyaluronic acid, gelatin and bioactive glass which are potentially useful for cell-based tissue engineering approaches using stem cells for chondrogenic differentiation. |
| 저자 |
Dibakar Mondal1, Yeowoori Lee2, Byeong Yeol Lee3, Young Ki Min4, Hun Mo Yang5, Byong Taek Lee6
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| 소속 |
1Institute of Tissue Regeneration, 2Department of Biomedical Engineering and Materials, 3College of Medicine, 4Soonchunhyang Univ., 5Chungnam 330-930, 6Korea. |
| 키워드 |
Hyaluronic acid; Gelatin; Bioactive glass; Bone regeneration; 3D scaffold
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| E-Mail |
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