| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
생체재료 |
| 제목 |
Systemic cellular delivery of therapeutic protein using bio-hybrid nanoparticles prevents acetaminophen-induced hepatotoxicity and liver injury |
| 초록 |
Acetaminophen (APAP) is one of the most frequently prescribed drugs and the leading cause of drug-induced liver toxicity and hepatic failure. Reactive oxygen species (ROS) is known to play critical roles in the pathogenesis of APAP-induced liver injury. Although superoxide dismutase (SOD) is an excellent ROS scavenger, its clinical implementation requires safe and effective delivery of the enzyme into the cells of the target tissue. Herein we combine a hydrophilic natural polymer with inorganic calcium phosphate for the facile preparation of an SOD-containing bio-hybrid nanoparticle having multiple functions such as liver-targeting property, endosomal escape function, and desirable stability both in the blood stream and the cells. The treatment of the bio-hybrid nanoparticles achieved the efficient hepatic cellular delivery of SOD via a systemic administration and resulted in efficient removal of ROS in the liver and remarkable improvement of APAP-induced liver injury in animals. |
| 저자 |
이민상, 김낙원, 이정은, Yin Yue, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
Calcium phosphate nanoparticles; Protein delivery; Systemic targeted delivery
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| E-Mail |
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