| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Synthesis of Superparamagnetic Iron Oxide Nanocubes and their stabilization by using PEO Based Prodrugs |
| 초록 |
Living anionic ring-opening polymerization of ethylene has been used for preparation of block copolymer. In this study, poly(ethylene oxide) (PEO) -b- poly(N-phenylmaleimide) was first synthesized by sequential monomer addition technique, followed by deimidation using hydrazine hydrate under the acidic condition leading to the generation of corresponding PEO -b- poly(cyclic hydrazide). The resulting compounds were found to be very efficient to be utilized for synthesis of polymer prodrugs such as PEO-Doxorubicin and PEO-Methotraxate (MTX) conjugates. Depending on the reaction condition, those conjugates became ‘smart’ drug-nanocarriers which could be used as polymeric stabilizers or fluorescent imaging materials. Superparamagnatic nanocubes were stabilized by these polymer prodrug conjugates. In this presentation, we report the preliminary results for preparation of the ‘smart’ materials to be used in the drug delivery system |
| 저자 |
시디크 아부 바카1, 김정안2, Jae Hyuk Lee3, Solji Park2, Sera Yang3, Youn Kim2, Gyusaang Youn3, Sungwoo Kim2, Youra Lee3, Ho-Jung Kang2, Jae Yeol Lee3
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| 소속 |
1경희대, 2Department of Chemistry, 3Kyung Hee Univ. |
| 키워드 |
iron oxide; nanocubes; drugs; polymer; DDS
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| E-Mail |
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