| 학회 |
한국화학공학회 |
| 학술대회 |
2015년 가을 (10/21 ~ 10/23, 일산 KINTEX) |
| 권호 |
21권 2호, p.1737 |
| 발표분야 |
생물화공 |
| 제목 |
Engineering Escherichia coli to overproduce cadaverine |
| 초록 |
Cadaverine (1,5-diaminopentane) is a five-carbon diamine that can be used for sustainable polymer production. Microbial production of cadaverine from renewable feedstock is a promising and sustainable alternative to the conventional petroleum-based chemical synthesis. Herein, we report a metabolically engineered Escherichia coli strain capable of overproducing cadaverine from glucose in minimal salts medium. With the pathways that lead to cadaverine degradation deleted, the final engineered strain produced 9.61 g/L of cadaverine with a productivity of 0.32 g/L/h by fed-batch fermentation. [This work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries from the Ministry of Science, ICT and Future Planning (MSIP) through the National Research Foundation (NRF) of Korea (NRF-2012-C1AAA001-2012M1A2A2026556).] |
| 저자 |
이상엽1, Hye Min Park2, Zhi-Gang Qian3, Ziwei Luo4
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| 소속 |
1MBEL, 2Dept. of Chemical and Biomolecular Engineering (BK21 Plus rogram), 3KAIST / BioInformatics Research Center, 4Institute for the BioCentury |
| 키워드 |
Metabolic engineering; Cadaverine; Escherichia coli
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| E-Mail |
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| 원문파일 |
초록 보기 |
