| 학회 |
한국공업화학회 |
| 학술대회 |
2013년 가을 (10/30 ~ 11/01, 대전컨벤션센터) |
| 권호 |
17권 2호 |
| 발표분야 |
포스터-정밀화학 |
| 제목 |
All-trans retinoic acid-incorporated nanoparticles of methoxy poly (ethylene glycol)-grafted-chitosan and its antitumor activity against CT-26 colon carcinoma cell |
| 초록 |
All-trans retinoic acid (ATRA)-incorporated nanoparticles were prepared using water-soluble chitosan (WSC) and methoxy poly(ethylene glycol)-grafted chitosan (ChitoPEG) copolymer to test its antitumor potential at in vitro and in vivo. ATRA-incorporated nanoparticles of WSC and ChitoPEG copolymer were prepared through ion-complex formation between chitosan and ATRA. Their antitumor potential was studied using pulmonary metastasis model of CT26 colon carcinoma cells. Nanoparticles were completely able to reconstitute into various aqueous solution without aid of cryoprotectants. Nanoparticles of ChitoPEG copolymer showed significantly longer blood plasma level than drug itself and WSC nanoparticles. Even though its antiproliferation activity of nanoparticles for CT 26 cells at in vitro was less than ATRA itself, antitumor activity at in vivo was higher than drug. |
| 저자 |
김동곤1, 박준규1, 남정표1, 최창용1, 장미경1, 정영일2, 나재운1
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| 소속 |
1순천대, 2양산부산대병원 |
| 키워드 |
All-trans retinoic acid; chitosan; pegylation; ion complex; polymeric micelle.
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| E-Mail |
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