| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 | 27권 1호, p.307 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Receptor-mediated delivery of all-trans retinoic acid(RA) to hepatocytes from 6-Galactosyl-β-CD |
| 초록 | Retinoic acid (RA), an endogenous metabolite of vitamin A, is hydrophobic and also known for an unstable material in light, temperature, oxygen and lipid peroxide. Its poor aqueous solubility also makes it difficult to be formulated into parenteral formulation. Cyclodextrins(CDs) are cyclic (α-1,4)-linked oligosaccharides of α-D-glucopyranose containing a relatively hydrophobic central cavity and hydrophilic outer surface. The most common CDs are α-, β-, and γ-CD, which consist of six, seven, and eight glucopyranose units, respectively. They are frequently regarded as a new group of pharmaceutical excipients. The inclusion complexation of hydrophobic drugs with β-CD are commonly chosen because the thermal dynamic stability is best in the three types of CDs. In this study, the inclusion complexation of RA with 6-Galactosyl-β-CD(Gal-β-CD) was checked for specific binding to asialoglycoprotein receptors(ASGPRs) on the cell membrane of hepatocytes. We checked several physicochemical properties of the inclusion complex of the Gal-β-CD/RA using NMR, circular dichroism, and differential scanning calorimetry(DSC). Also, gene expression of the hepatocytes between Gal-β-CD/RA and RA itself was compared. |
| 저자 | 서석진1, 김상헌*2, T. Akaike*3, 최윤재, 조종수 |
| 소속 | 1서울대, 2*Dept. of Biomolecular Engineering Tokyo Institute of Technology, 3Japan |
| 키워드 | |
