| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 |
23권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Recognition and release properties of thermosensitive allopurinol-imprinted starch based biomaterial films. |
| 초록 |
In this study, functional biomaterials were prepared by mungbean starch (MBS), polyvinyl alcohol (PVA), poloxamer (PX) as a thermosensitive material, sodium benzoate (SB) as a photoinitiator, allopurinol (ALP) as the target drug, and plasticizers. ALP imprinted biometerial films were prepared by using casting method and UV curing process. Recognition properties were evaluated by absorption experiments at different concentrations of ALP. The results indicate that thermosensitive ALP imprinted biomaterial films have the binding site for ALP. The release properties of ALP was examined with the change of pH and temperature. The results indicate that ALP release in pH 10.0 and high temperature was higher than in pH 4.0 and low temperature. In addition, the applicability as a transdermal drug delivery patch was verified by the artificial skin test. |
| 저자 |
김한성1, 정헌호1, 이창문1, 심왕근2, 윤순도1, 변헌수1
|
| 소속 |
1전남대, 2순천대 |
| 키워드 |
functional molecularly imprinted biomaterials; Recognition properties; allopurinol; binding site; release properties
|
| E-Mail |
|
