| 초록 |
Bio-inspired from unusual adhesion and crosslinking chemistry of mussels, catechol-functionalized chitosan-based hydrogel was synthesized for tissue adhesives. In a highly crosslinked mussel adhesive pad, catechol moiety (ortho-dihydroxyphenyl group) in unusual amino acid DOPA (3,4-dihydroxyphenylalanine) plays an important role in adhesion on various substrates and chemical bonding with amine, thiol, and other catechols. The chitosan macromolecule conjugated with multiple catechol groups was observed to crosslink with each other to produce solidified hydrogel instantaneously. The fabricated chitosan-based hydrogels exhibited robust gelling and environment-sensitive behaviors. The novel chitosan-based hydrogel is expected to be usefully exploited as injectable drug delivery depots, tissue engineering hydrogels, tissue adhesives, and anti-bleeding materials. |
