| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Thermo/redox dual-stimuli-responsive nanocarriers fabricated by catecholic polymer hybrids for targeting antitumor treatment |
| 초록 |
Stimuli-responsive polymer nanocarriers mediated drug delivery is one of the most promising platforms for targeting antitumor treatment. In this work, by using a combination of reversible addition fragmentation chain transfer polymerization (RAFT) and ring opening polymerization, we present an efficient approach for preparing a series of disulfide-containing amphiphilic polypeptide hybrids, poly(N-isopropylacrylamide)-block-poly(3,4-dihydroxy-L-phenylalanine) (PNIPAM-b-PDOPA). After the aminolysis of the RAFT end group and the deprotection of acetyl group, the resulting hybrids were able to self-assemble into stabilized and uniform micelles in which doxorubicin is efficiently encapsulated. The in vitro cell viability assays results illustrated that the PNIPAM-b-PDOPA hybrid bioconjugates might serve as highly biocompatible and multifunctional nanocarriers for practical applications. |
| 저자 |
yu zhang1, saji uthaman2, 김일1
|
| 소속 |
1부산대, 2충남대 |
| 키워드 |
nanocarriers; polymer hybrids
|
| E-Mail |
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