| 초록 |
The regulation of natural protein and peptide assemblies is deeply related to the pathological events involving various diseases. However, natural and synthetic peptides can provide new inspiration for creating advanced nanobiomaterials. The rational design and supramolecular polymerization of synthetic peptide amphiphiles give rise to a variety of self-assembling hierarchical nanoarchitectures through strong intermolecular interactions under physiological medium. By incorporating and modifying bioactive side chain, customized nanobioagent are now available. Their secondary structures and subsequent conformational changes provide structural diversity in the resultant nanoparticles. In this talk, I will discuss how to control nanostructure of synthetic peptides and fabricate therapeutic nanoagent by co-assembly of each peptide with specific functionality such as specific cell-targeting, cell-penetrating, diagnostics, and antimicrobial activity. |
