| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
The drug loading/releasing capability of glutathione-responsive peptide amphiphile vesicles controlled by positionable disulfide-bridges |
| 초록 |
In anticancer drug delivery system, delivering and releasing the drugs to the target tumor cells is challenging due to systematic toxicity and side effects on normal cells. The self-assembly of peptide amphiphiles (PAs)-based vehicles have garnered attention due to their biocompatibility and a dual loading capability for hydrophilic and hydrophobic payloads. However, controlled stability in physiological media remains a challenge for efficient drug encapsulation and release. Here, the glutathione-responsive drug-releasing vesicles were developed by self-assembly of PA with cysteine which can form disulfide-linkages. The PA vesicles demonstrated different drug loading capacities and releasing efficiencies as functions of the location and number of disulfide-linkage during assembly. This research provide a biocompatible peptide design for the synthesis of efficient drug-delivery vehicles and serve as a solid foundation for further nanocarrier developments for biomedical applications. |
| 저자 |
김하연, 김인혜, 황준호, 이은지
|
| 소속 |
광주과학기술원 |
| 키워드 |
self-assembly; peptide nanostructutre; glutathione-triggered drug delivery; disulfide bridge
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| E-Mail |
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