| 초록 |
Ferrocene is a recent, cutting-edge ROS-responsive organometallic compound which has the potential to be used as an alternative to traditional drug delivery nanocarriers due to their unique reversible redox properties. In this study, we developed the ferrocene nanoparticles(FNPs) and their use as a highly ROS-responsive and stable drug delivery carrier. The library of ferrocene polymers were conveniently synthesized by free radical polymerization and designed by adjusting the ratio of the monomers. Stability improvements were evaluated by monitoring changes in the appearance and diameter of the NPs and the physicochemical properties of the FNPs were characterized by DLS and TEM. FNPs were quickly increasing particle size and releasing encapsulated model drug in the polymeric nanocarriers by redox agent H2O2. Finding that, the drug was swiftly released by selectively reacting to redox environments in cancer cell as well as their applications in controlled release. |
