| 초록 |
We constructed dimeric alpha-helical peptide bundles based on leucine (L) and lysine (K) residues for both efficient cell penetration and inhibition of the Tat–TAR interaction. Unlike other cell penetrating peptides, which can show the cell penetrating activity only at micromolar concentrations, our cell penetrating peptides show very efficient cell penetration at low nanomolar concentrations. Also, the LK dimers can effectively inhibit the elongation of the TAR transcript at the concentration. The effective inhibition of HIV-1 replication strongly suggests that the LK dimer has strong potential as an anti-HIV-1 drug. |
