| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Drug delivering MR imaging agent; DOX@TCL-SPION for in vivo cancer treatment and diagnosis |
| 초록 |
We produced a novel drug delivering MR imaging agent, DOX@TCL-SPION for in vivo cancer treatment and diagnosis. We synthesized anti-biofouling polymer coated thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) as a MR contrast agent, and then loaded DOX by titration method to prepare stable physical complex. The maximum loading amount of DOX was 2 wt %, and its hydrodynamic size was approximately 21.3 nm. After i.v. injection of DOX@TCL-SPION to LLC allograft mice, a noticeable darkening appeared in the tumor area in the T2 weighted MR imaging with a RSE value of about 58 %. After sacrifice mice, ex vivo organs in IVIS images indicated exclusively intense fluorescence signal of the DOX in the tumor. Consistent with this, DOX@TCL-SPION (0.64 dox eq.mg/kg) exhibited superior therapeutic outcome, when compared with free DOX (0.64 mg/kg or 5 mg/kg). Therefore, we anticipate that DOX@TCL-SPION may be utilized to develop novel therapeutic and diagnostic modalities. |
| 저자 |
유미경1, 박진호1, 정용연2, 민정준2, 전상용1
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| 소속 |
1광주과학기술원, 2전남대 |
| 키워드 |
nanoparticles; drug delivery; MR imaging agents; antitumor agents
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| E-Mail |
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