| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Branched polymeric photosensitizer targets influenza envelope viral protein for directly inactivation |
| 초록 | Conventional drugs against influenza virusefficacy were declined in treatment because of mutations and resistance of thevirus. We have synthesized branched polymeric photosensitizer (BPP), which hasreceptor abundant structure, that was designed to multivalent interaction withinfluenza virus and induced photochemically virus inactivation. BPP wascomposed of polysaccharide, biomimetic receptor, and a photosensitizer. It wasconfirmed via experiment of molecular level that the BPP interacts with virusenvelope protein. Furthermore, the interaction between BPP and virus isvisually verified via the actual images. BPP disrupted the virus infection moreeffectively than conventional antiviral drugs. The antiviral effect of BPP isincreased in light-irradiation by viral membrane disruption to photochemicaleffect. In addition, the virus inhibitory effect was confirmed in animal modelsagainst influenza virus. These features provide a new type of treatmentparadigm for viral infection. |
| 저자 | 정하윤, 이정주, 이장수, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | antiviral drug; photochemical inactivation |
