| 초록 |
In recent years, malaria is a mosquito-borne infectious disease and one of the fatal illnesses. Various malaria diagnostic kits such as lateral flow assay (LFA), fluorescent assay and so on, have been developed for early malaria detection. Although, those diagnostic tools have provided attractive advantages, the limitations such as low sensitivity and storage remains as challenges. In this research, we provided quantum dots (QDs) based LFA with high sensitivity and long-term stability. Especially, QDs were synthesized under liquid state, so they have high stability and quantum yield. Moreover, the surface of the QDs was modified with carboxylic groups and the HRP2 antibody were easily conjugated by EDC-NHS coupling reaction. The HRP2 antibody-conjugated QDs were used for LFA application and they showed higher detection level comparing to the conventional Au nanoparticle-based LFA kits. |
