| 초록 |
Polymer bound chiral auxiliaries, which enable the asymmetric synthesis of libraries of homochiral compounds, have received increasing interest within the last few years. Such solid supported chiral auxiliaries offer some advantages as compared to their application in the solution phase, including a simple ‘filtration’ procedure for the isolation of the desired compounds or the recovery of the expensive chiral auxiliaries, and their possible extension to a continuous flow system. In addition, the microenvironment of the polymeric backbone could lead to an improvement in the stereoselectivity for a given transformation. In this study, a novel Wang resin supported 2-amino-2-oxazoline chiral auxiliary was synthesized via 6 steps. Its efficiency in asymmetric alkylation reactions will be discussed. |
