| 초록 |
For an efficient drug delivery system (DDS), releasing the drug at a desired site is essential as well as insuring the stability of the drug under physiological conditions. Due to the acidic conditions of tumor cell, dynamic imine linkage can be a key chemistry for a stimuli-responsive DDS. In this study, we synthesized the novel diblock copolyethers composed of functional epoxide monomers, ethoxy ethyl glycidyl ether and a novel azido-hexyl glycidyl ether, via sequential anionic ring-opening polymerization using organic superbase. Acetal group was deprotected to hydroxyl group and azide group was modified to amine through Staudinger reduction. The prepared double hydrophilic block copolymer was conjugated with an anticancer agent, cinnamaldehyde, through the imine linkage to afford the amphiphilic block copolymer to self-assemble into a polymeric micelles. We anticipate this dynamic imine linkage will afford a conjugation of various functional therapeutic agents for a smart DDS. |
