| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Multifunctional Hybrid Scaffold with bECM/Mg(OH)2 and PDRN-BMP2 Nanocomplex using Human Fetal MSCs for Bone Regeneration |
| 초록 |
Poly(lactic-co-glycolic) acid (PLGA) has been widely used as biomedical materials due to its great biocompatibility and biodegradability. However, there are considerable hurdles that the byproducts of PLGA cause an acidic environment, and the synthetic polymer has a lower mechanical property. Here, we have prepared a PLGA combined with bone extracellular matrix (bECM) hybrid scaffold with magnesium hydroxide [Mg(OH)2] to enhance mechanical property and anti-inflammatory. We verified that human fetal derived MSCs (hfMSCs) demonstrated a great potential to osteogenesis. BMP2 is known for osteogenic differentiation of MSCs. Since the initial release of BMP2 has side effects, we induced the controlled release of BMP2 by forming nanocomplex (NC) with polydeoxyribonucleotide (PDRN). The hybrid scaffolds improved the ALP activity and bone regeneration capacity. In conclusion, we suggest that hybrid scaffold immobilized with NC and hfMSCs has a high synergistic effect on bone regeneration. |
| 저자 |
이준규1, 김다슬2, 허윤1, 김태형2, 한동근1
|
| 소속 |
1차의과학대, 2중앙대 |
| 키워드 |
PLGA; Magnesium hydroxide; BMP2; Nanocomplex; Bone regeneration
|
| E-Mail |
|
