| 초록 |
PLGA has been widely used as biomedical materials. However, there are considerable obstacles that the degradation byproducts of PLGA cause an acidic environment of implanting site, and the synthetic polymer has a lower mechanical property. In this study, we have developed a PLGA hybrid scaffold containing magnesium hydroxide [Mg(OH)2] and bone-extracellular matrix (bECM) to enhance a mechanical property and suppress anti-inflammation. Recently, many researchers use mesenchymal stem cells (MSCs) for bone tissue engineering. The human fetal MSCs demonstrated better potential to osteogenic differentiation than other MSCs. Bone morphogenetic protein-2 (BMP2) is known for osteogenic differentiation of MSCs. However, since the initial release of BMP2 has a side effects, we induced the controlled release of BMP2 by forming nanocomplex with polydeoxyribonucleotide (PDRN). In conclusion, this study implies that the hybrid scaffold and hfMSCs have a synergistic effect for bone regeneration. |
