| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
약물 및 유전자 전달용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Development of a composite scaffold for osteochondral regeneration |
| 초록 |
The importance of the study for the regeneration of an osteochondral composite has emerged as being an aging society. In this study, an osteochondral composite scaffold was fabricated by combining a sintering method and a gel pressing method. A PLGA/beta-TCP scaffold was used for the part of bone and a PLCL scaffold was used for the part of cartilage. The compressive modulus and the porosity of the scaffold were measured by an Instron and a mercury intrusion porosimeter, respectively. The interconnectivity and the structure of the scaffold were observed by SEM. Also, the bioactivity and the biocompatibility were tested in vitro and in vivo experiments. From the results, we confirmed that our osteochondral composite scaffolds had appropriate physiological and biological properties for the regeneration of osteochondral composites; consequently, it is considered that they could be useful for the treatment of osteochondral defects. |
| 저자 |
김수희1, 김수현1, 정영미1, 김상헌1, 홍정호2
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| 소속 |
1한국과학기술(연), 2고려대 |
| 키워드 |
bone; cartilage; osteochondral scaffold; novel sintering method; PLGA; beta-TCP; PLCL
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| E-Mail |
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