| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Bile acid functionalized beta glucan as antigen delivery systems: towards oral vaccination |
| 초록 |
Oral vaccination is the most efficient way to stimulate both cellular and humoral immune responses at systematic and mucosal site. Due to challenges in delivery routes its application remains limited for human use. Beta glucans are macroparticles that can encapsulate antigens, target intestinal M-cells and induce mucosal immunity. We designed bile acid (TCA) conjugated beta glucan carrier for targeting M-cells which is capable of delivering any encapsulated antigen successfully that leads to mucosal immunity against harmful pathogens. The physical characterizations and stability analysis was performed to check the successful development of nanocarrier and toxicity effect towards cells in vitro. The formulation is cell viable and able to encapsulate enough antigen. We believe, the designed antigen carrier can stimulate immune response and can be an efficient delivery system for oral vaccination. |
| 저자 |
Mohammad Nazmul Hasan1, 안정만2, 이용규3
|
| 소속 |
1한국교통대, 2Department of Chemical and Biological Engineering, 3Korea National Univ. of Transportation |
| 키워드 |
Beta glucan; oral vaccination; bile acid; M-cell targeting; mucosal immunity
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| E-Mail |
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