| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
In vitro photodynamic effects of dectin-1 receptor targeted-photoactivatable nanoagents on atherogenic cells |
| 초록 |
Atherogenic cells such as macrophages and foam cells have critical roles in the initiaion and progression of atherosclerosis and have been considered an important biomarker for targeted imaging and inflammatory-disease therapy. It is known that these cells express dectin-1 receptos. Here, we prepared the specific dectin-1 receptro targetable and photoactivatable nanoagents by physical loading of chlorin e6 (Ce6) into single strand beta-glucan (Glu). Glu/Ce6 formed nano-sized particles and generate single oxygen under laser irradiation. Also, it was internalized via receptor medicated endocytosis and notably caused apoptosis of activated macrophages and foam cells under laser irradiation. |
| 저자 |
안재원, 김진혁, 박경순
|
| 소속 |
중앙대 |
| 키워드 |
photodynamic therapy; beta-glucan; chlorin e6; atherosclerosis
|
| E-Mail |
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