| 학회 |
한국재료학회 |
| 학술대회 |
2011년 봄 (05/26 ~ 05/27, 제주 휘닉스 아일랜드) |
| 권호 |
17권 1호 |
| 발표분야 |
D. Health and Biological Materials(생체 및 의용재료) |
| 제목 |
Anticancer loaded multi-wall carbon nanotube for targeting tumors |
| 초록 |
Flat form technology for constructing anticancer loaded multi-walled carbon nanotubes (mwCNTs) was introduced in this study. Conventional anticancer drugs, such as MTX (Methotrexate), cisplatin, DOX (Doxorubicin hydrochloride), DAU (Daunorubicin) and EPI (epirubicin) were bio-conjugated with folic acid (FA) for selective targeting tumor cells. Loading efficiencies of the used anticancer drugs on mwCNTs have shown different order of bindings depending on the molecular bind affinity of NH (amine) formation on mwCNTs. MTT assays have shown increased selective target efficiency of FA conjugated mwCNTs on breast cancer cell growth inhibition. All results collectively indicated promising application of mwCNTs as a smart inorganic nanomaterial for selective targeting drug delivery vehicle at tumor tissues. |
| 저자 |
Wenping Wang1, Jungil Choi2, Sang Soo Kang3, Tae-Hyun Nam4, Dongwoo Khang2
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| 소속 |
1School of Materials Science and Engineering and PRC for NBECS, 2Gyeongsang National Univ., 3Department of Anatomy, 4Institute of Health Science and School of Medicine |
| 키워드 |
Anticancer Drugs; Carbon Nanotubes; Bio-Conjugation; Tumor; Selectivity
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| E-Mail |
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