| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Non-invasive monitoring of the neuronal stem cell proliferation within injectable and mechanically tunable gelatin hydrogels |
| 초록 |
Recently, the injectable hydrogels have been used in regenerative medicine to provide biomechanical support for stem cells and to fill up lost tissue area together with stem cells. In this study, in situ forming and mechanically tunable gelatin hydrogels were developed as an injectable matrix for tissue regenerative medicine. The hydrogel was rapidly formed using horseradish peroxidase and H2O2. Their mechanical properties could be controlled by changing the catalysts concentrations. In vitro/in vivo studies were investigated using stable cell line transduced with an enhanced firefly luciferase retroviral vector within the hydrogel formed with the different stiffness. The luciferase activity was monitored by bioluminescence imaging. Obtained results demonstrated that the non-invasive monitoring system using the injectable hydrogels may be a powerful tool to evaluate the characteristics of stem cells within the matrix for therapeutic application in tissue regenerative medicine. |
| 저자 |
박경민1, 황도원2, 심혜경2, 이동수2, 정윤기1, 박기동1
|
| 소속 |
1아주대, 2서울대 |
| 키워드 |
injectable hydrogel; biomimetic scaffold; non-invasive monitoring
|
| E-Mail |
|
