| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Biomimetic PLGA/ECM 3D porous scaffolds for kidney tissue regeneration |
| 초록 |
Chronic kidney disease is now recognized as a major health problem, but current therapies have many limitations. Consequently, biodegradable scaffolds to help repairing injured tissue are emerging as a promising approach in the field of kidney tissue engineering. Poly(lactic-co-glycolic acid) (PLGA) is a useful biomedical material, but its insufficient biocompatibility impeded renal regeneration. In this work, we developed extracellular matrix (ECM) incorporated PLGA (PLGA/ECM) porous scaffolds as a cell supporting material. PLGA/ECM scaffolds were prepared and characterized through various analyses. Cell proliferation on the scaffolds increased with an increase in ECM concentrations. The PLGA/ECM scaffold was shown to be an effective matrix for the reconstitution of glomerulus in partially nephrectomized mice, compared with only PLGA control. These results suggest that the ECM incorporated PLGA 3D porous scaffolds could be one of the promising materials for kidney tissue regeneration. |
| 저자 |
김윤아1, 이유진1, 전소영2, 정윤기1, 권태균2, 고원건3, 한동근1
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| 소속 |
1한국과학기술(연), 2경북대, 3연세대 |
| 키워드 |
PLGA scaffold; ECM; kidney; 3d porous
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| E-Mail |
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