| 초록 |
Thermogel is a hydrogel which changes its phase sol to gel when temperature increases. Unlike most polymer solutions which undergo gel-sol transition, thermogel has reversible phase transition and that can be applied as an injectable formulation which makes it possible having non-invasive in situ implantation without surgery. Due to its unique property, thermogel has many potentials to be applied to various ways in biomedical fields such as drug delivery system, injectable tissue engineering, 3D cell culture scaffold. Synthesized by ring-opening polymerization, PEG-PCL-PEG triblock copolymer is investigated. PEG-PCL-PEG triblock copolymer is a thermogel which can transform its phase sol-gel around body temperature at 33 wt% concentration. Not only PEG-PCL-PEG triblock copolymer has features of thermogel but also has biodegradable and biocompatible properties. It is shown that PEG-PCL-PEG triblock copolymer has potentials to be applied as a biomedical material. |
