| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Bioabsorbable nanofibrous sheets containing blood clotting factors for use as hemostatic agents |
| 초록 |
Hemostatic agents have been used in surgical operation for many years to control bleeding. In this study, we fabricated poly(vinylpyrrolidone) nanofibers containing calcium chloride and thrombin to use as a novel non-woven hemostatic agent. PVP nanofibrous sheets were fabricated by electrospinning of 10 wt% PVP aqueous ethanol solution containing thrombin and calcium chloride. Electrospun PVP nanofibrous mat structures revealed randomly aligned fibers with average diameter of 580 nm. Surface characteristic of PVP nanofiber were confirmed to be soluble and hydrophilic surface determined by water contact angle measurement. PVP nanofibers showed a relatively low cytotoxicity and the cellular survival rate was more than 90%. In vitro whole blood coagulation experiment showed expeditious blood coagulation within 3 minutes after contact with fabricated nanofibrous sheet. These results suggest that electrospun PVP nanofibers will be a promising hemostatic agent to reduce massive blood loss. |
| 저자 |
김병남1, 이지영1, 김선종2, 김은진2, 백인수2, 권오형1
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| 소속 |
1금오공과대, 2M.I.Tech |
| 키워드 |
Nanofiber; hemostasis; coagulation factor; trombin
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| E-Mail |
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