| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 | 27권 1호, p.273 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation and Characterization of the 1,25(OH)2 Vitamin D3-loaded Poly(lactide-co-glycolide) Scaffolds for Tissue Engineered Bone |
| 초록 | 1,25(OH)2 vitamin D3-loaded biodegradable PLGA scaffolds are synthetic bone substitutes that promote bone formation by osteoconduction and osteoinduction. 1,25(OH)2 vitamin D3 plays as a regulator of osteogenic differentiation of bone marrow stromal cell (BMSC). These scaffolds were confirmed in vivo osteogenic potential for tissue engineered bone. Biodegradable scaffolds were fabricated by salt leaching/solvent casting method. Poly(lactide-co-glycolide) (PLGA 75:25, Mw 90000 g/mole) was dissolved into methylene chloride and this solution was mixed with sodium chloride and 1,25(OH)2 vitamin D3. molded, and then leached in an aqueous solution. The scaffolds had relatively homogeneous pore structures throughout the matrix and showed an average pore size in the range 150~280 μm and over 90% porosity. From the results, this sustained, besides, constant localized release system can potentially provide 1,25(OH)2 vitamin D3 and encourage calcium and phosphate, which plays an important role for osteoconduction and osteoinduction. These scaffolds may be used for the applications of bone regeneration. In vivo and detailed studies on the 1,25(OH)2 vitamin D3-loaded scaffolds are now in progress. Acknowledgment: This work was supported by MOWH (IMT-2000, 01-PJ11-PG9-01NT00-0011). |
| 저자 | 이상진1, 이동헌*2, 강길선*3, 이영무, 이해방** |
| 소속 | 1한양대, 2*전북대, 3**한국화학(연) |
| 키워드 | |
