| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
대학원생 구두발표(발표10분) |
| 제목 |
Bioabsorabable Bone Plates Enabled with Local, Sustained Delivery of Alendronate |
| 초록 |
Bioabsorabable bone plates and screws have widely been applied for treatment of bone fractures in orthopedic surgery. However, the patients with osteoporosis may suffer from delayed bone repair, which was not yet resolved with the conventional bone fixation systems. In this work, therefore, we employed a bioabsorbable bone plate, already in clinical use and added the functionality of sustained, local delivery of a drug, alendronate. To realize sustained, local drug delivery, we coated the bone plate with a biocompatible polymer loaded with the drug. To have the coating adhere well to the surface of the bone plate, we used azidobenzoic acid modified chitosan (i.e., Az-CH), which was photocrosslinked by UV light (335 nm). As we performed the in vitro drug release study, the drug was released from the coating at a rate of 4.03 μg/day for 60 days in a sustained manner.#These authors contributed equally. |
| 저자 |
허우준#1, 박민#2, 김명훈2, 이승호2, 박천권2, 최태현†1, 최영빈2
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| 소속 |
1서울대병원 성형외과 및 의생명(연), 2서울대 |
| 키워드 |
bone plate; chitosan; coating; crosslink; sustained delivery
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| E-Mail |
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