| 학회 |
한국화학공학회 |
| 학술대회 |
2003년 가을 (10/24 ~ 10/25, 한양대학교) |
| 권호 |
9권 2호, p.1942 |
| 발표분야 |
분리기술 |
| 제목 |
Nonlinear Mathematical Model of Preparative Chromatography |
| 초록 |
Enantiomers have the same physical properties without optical property, and exhibited different activity in human body. One of enantiomer pair has medical activity, and the other shows seriousness side effect. Because of difficult synthesis, separation by LC with CSP has been widely used. In this study, the separation condition for racemic bupivacaine was investigated by mathematical model with competitive Langmuir isotherm to find the optimum feed condition, injection volume and injection concentration.The parameters of competitive Langmuir isotherm were assumed and fitted to the experimental data by solving the mathematical adsorption equations with commercially available gPROMS. For each racemic compound, mass transfer coefficients k were obtained by parameter estimation and maximum likelihood method. The agreement of elution profiles between the experimental data and the calculated values was fairly good. In order to find the optimum separation condition, simulations were carried out to determine the feed conditions. It was experimentally confirmed that for the feed conditions to separate preparatively racemic bupivacaine.
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| 저자 |
한순구1, 최영재1, 정성택1, 이윤우2, 김재덕2, 노경호1
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| 소속 |
1인하대, 2한국과학기술원 |
| 키워드 |
Bupivacaine; Chiral Separation; Mathematical Model; HPLC; Optimum Condition |
| E-Mail |
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| 원문파일 |
초록 보기 |
