| 학회 |
한국고분자학회 |
| 학술대회 |
2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 |
28권 2호, p.165 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Plasma protein adsorption to anion substituted poly(vinyl alcohol) membranes |
| 초록 |
Anion-substituted poly(vinyl alcohol)(PVA) membranes, carboxymethylated PVA and sulfonated PVA, were prepared, and the effects of these substitutions on the plasma protein adsorption were studied by one- and two- dimensional gel electrophoreses, and immunoblotting. When Cuprophane was used as a negative control, the amount of total proteins bound to samples decreased on the order of Cuprophane, PVA, C-PVA and S-PVA, which is attributed to the effects of surface characteristics of samples, such as surface tensions and electrostatic properties, on the adsorption of proteins to surfaces of materials. Results revealed albumin was the most abundant protein in all samples. Proportion of adsorbed fibrinogen to S-PVA exceed those for PVA and C-PVA, whereas S-PVA exhibited lowest IgG adsorption affinity among the samples. |
| 저자 |
전흥재1, 유규은2, 임향숙1, 박종원3, 김재진4, 이영무5
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| 소속 |
1가톨릭의대 생명의과학과, 2가톨릭의대 의생물학과, 3가톨릭의대 혈액종양내과, 4서울 과학기술(연), 5한양대 화학공학과 |
| 키워드 |
carboxymethylated poly(vinyl alcohol); sulfonated poly(vinyl alcohol); hemodialysis membrane; plasma protein adsortion
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| E-Mail |
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