| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
고분자가공/복합재료 |
| 제목 |
Changing the properties of catechin by polymer-directed crystallization |
| 초록 |
Engineering the properties of pharmaceutical ingredients by crystallization has been an important subject of research and development. Adding a small quantity of polymer as an additive during crystallization could tailor the various properties which could bring a lot of advantages. We used a cooling crystallization method for catechin in presence of polymers with the hypothesis that we can engineer the crystals of catechin in a wide range. The particle sizes of catechin were distinctly reduced with using hydroxypropyl methylcellulose, polyethyleneimine branched (PEI) and polyvinyl alcohol. The crystal melting point of catechin with PEI was not observed. These results reflected the release behavior of catechin. Catechin with PEI showed a sustained release behavior. Those results might be affected by the surface adsorption of polymers onto the surfaces of growing crystals. This method is a very simple method and it can be used for tailoring a lot of other active ingredients in many areas |
| 저자 |
김형주, 최규형, 이종휘
|
| 소속 |
중앙대 |
| 키워드 |
polyphenol; polymer; crystallization; catechin
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| E-Mail |
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