| 초록 |
Nanofibers prepared by electrospinning has been widely investigated in tissue engineering field, because they have a three-dimensional structure like the natural extracellular matrix (ECM). Thus, electrospun nanofibers are expected to be utilized for the effective wound treatment. In this work, we successfully prepared the nanofibrous patch including gelatin and hyaluronic acid via electrospinning and functionalized with catechol group. The successful formation of patch was confirmed by NMR, UV-vis spectrum and FTIR analysis. In addition, it was confirmed that the physicochemical, mechanical properties and cell activity were improved by increasing the content of catechol groups. Moreover, animal experiment confirmed that our nanofiber patch can accelerate wound healing as well as hemostasis compared to the untreated group. Taken together, the catechol-functionalized nanofiber patch is expected to be exploited for various tissue engineering application. |
