| 초록 |
Herein, we reported a small molecular catalyst immobilized chitosan conjugates, chitosan-g-hematin for facilitating catechol-catechol/catechol-amine cross-linkings to rapidly form chitosan hydrogels. The hematin oxidizes catechols mimicking the biological role of oxidoreductase. Chitosan oligosaccharide was grafted with multiple hematin groups for the purpose of obtaining a biocompatible, stable and water-soluble biocatalyst for in situ gelling hydrogels. Chitosan-g-hematin catalyst showed improved solubility in physiological conditions and the conjugated hematin exhibited excellent catalytic properties to form polymer-catechol hydrogels within 5 minutes. In addition, chitosan-g-hematin had excellent cell viability in vitro. This hematin-conjugated chitosan oligosaccharide was useful to fabricate the catechol-functionalized polymer hydrogels with controlled physicochemical properties such as adhesion force, mechanical strength, and gelation time. |
