| 초록 |
Alginate, a natural polysaccharide that has shown great potential as a cell scaffold for the regeneration of many tissues, has only been nominally explored as an electrospun biomaterial for such applications due to cytotoxic chemicals that have typically been employed during both nanofiber formation and biopolymer crosslinking. However, alginate cannot be electrospun by itself due to inadequate entanglements from inter-chain charge repulsions, and therefore is often co-spun with poly(ethylene) (PEO). Our laboratory recently developed electrospun cell adhesive peptide modified alginate, polyionic complexed chitosan-alginate, biodegradated photocrosslinkable alginate, and highly three-dimensional alginate nanofibers using electrospinning process. There are challenges that may need to be addressed for used of alginate based nanofibers in regenerative medicine application. |
