| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Injectable cell-cross-linked gels for tissue engineering |
| 초록 |
Alginate has been widely used for tissue engineering due to biocompatibility, simple gelation behavior, and ease of administration into the body in a minimally invasive manner. We hypothesized that mechanical strength and gelation time of cell-cross-linked gels can be regulated by addition of minimal amount of ionic cross-linking molecules, as well as by variation of alginate composition. An RGD-modified alginate solution, mixed with minimal amount of calcium sulfate, did not show significant changes in the viscoelastic properties. However, G' of the solution was substantially increased when mixed with NIH 3T3 cells, indicating the formation of stable and strong cell-cross-linked gels. The addition of small amount of divalent cations was able to enhance the physical properties of cell-cross-linked gels and reduce gelation time, depending on the molecular composition of alginate backbone. |
| 저자 |
박홍현1, David J. Mooney2, 이근용3
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| 소속 |
1한양대, 2Division of Engineering and Applied Sciences, 3Harvard Univ. |
| 키워드 |
alginate; hydrogel; RGD; cell-cross-linking; tissue engineering
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| E-Mail |
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