| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Dual-Color-Emitting Carbon Nanodots for Theranostic Applications |
| 초록 |
Carbon nanodot has been investigated as a new multifunctional nanoparticle for wide fields of applications. In this work, we demonstrate a dual color-emitting carbon nanodot (DC-CND) by introducing 4-octyloxyaniline. DC-CNDs transferred to aqueous solution using poly(styrene-co-maleic anhydride showed high cell viability on normal and cancer cell lines. We have carried out in vitro cellular imaging of DC-CNDs, and DC-CNDs showed strong multicolor fluorescence signals changed by the excitation wavelength. Moreover, in vivo optical imaging visualized the biodistribution of intravenously injected DC-CNDs and it demonstrated its potency as an in vivo bioimaging agent. We also performed light-triggered activation of ion channel, channelrhodopsin-2, as a proof-of-concept study of optogenetics. Calcium imaging visualized elevation of calcium level after photoexcitation of DC-CNDs. DC-CNDs can be used for activation of two different ion channels depending on excitation wavelength. |
| 저자 |
김혜민1, 권우성2, 한세광3
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| 소속 |
1(주)화이바이오메드, 2숙명여자대, 3포항공과대 |
| 키워드 |
Carbon nanodot; Multicolor bioimaging; Optogenetics
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| E-Mail |
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