| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
Korea-Japan Joint Symposium: Advanced Functional Polymers for Bio- and Environmental Application (영어 |
| 제목 |
Biomaterials for Cellular Reprogramming and Origami-based Tissue Engineering |
| 초록 |
Lineage conversion from one somatic cell type to another is an attractive approach for deriving specific therapeutic cell generation. We report the development of a direct conversion methodology in which cells are transdifferentiated through a plastic intermediate state induced by exposure to non-integrative minicircle DNA (MCDNA)-based reprogramming factors, followed by differentiation into myoblasts. This methodology for direct lineage conversion from chondrocytes to myoblast represents a novel non-viral Method to convert hard-to-transfect cells to other lineage. Furthermore, we present a novel method for assembling biofunctionalized paper into a 3-dimensionally (3D) structured complex scaffold system for reliable tissue regeneration using an origami-based approach. We show that the paper-based scaffold can be folded freely into 3D tissue-like structures by simple origami-based method. |
| 저자 |
황석연 |
| 소속 |
서울대 |
| 키워드 |
Tissue engineering; Reprogramming; Origami
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| E-Mail |
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