| 초록 |
In this study, cationic methyl cellulose derivative was conjugated with cholic acid (CA) for drug delivery system. First, Methyl cellulose (MC) was oxidized and conjugated with polyethylenimine (MW 800 Da). Then, Methyl cellulose-polyethylenime (MCPEI) was further modified with cholic acid. In this way, cholic acid conjugated amphiphilic copolymer (MCPEI-CA) was synthesized for drug delivery system. It was expected to form nanoparticles by hydrophobic interaction which can encapsulate hydrophobic drugs. The chemical structure and the critical aggregation concentration of MCPEI-CA was examined. After doxorubicin (DOX) encapsulation, about 250 nm sized nanoparticles were formed and the drug loading content and efficiency were analyzed. Through the MTT assay, specific cytotoxicity of MCPEI-CA toward the cancer cells and anticancer activity of MCPEI-CA/DOX, even for the case of MDR cells, were confirmed. These results show the potential of the MCPEI-CA as a drug delivery system. |
