| 초록 |
Chitosan has properties such as biocompatibility and biodegradability. It is widely used in the medical field as a biomaterial for drug delivery. Therefore, In this study, Chitosan derivative were used to form drug-containing particle and to make sustained drug effect to injection site. Azido group was introduced into the gelatin for preparation of UV-curable Chitosan derivative. If Az-Chitosan particle form was injected into the body, it was slowly biodegraded and made a long-lasting effect on a certain site. 1H-NMR and FT-IR spectroscopy were demonstrated that azido group was introduced into Chitosan. The ability to encapsulate drug was confirmed by fluorescent protein using fluorescence microscope. Based on these characteristics, Az-Chitosan is expected to be application in medical field. |
