| 초록 |
The CLA was simply coupled to poly(ethylene glycol) (PEG) at the melting state of PEG without solvents or catalysts through ester linkages between the carboxylic group of CLA and the hydroxyl group of PEG. PEGylated CLA (PCLA) promotes adipocyte delipidation, in part by promoting lipolysis, which may result from ERK-dependent alterations in perilipin and ADRP gene expression, protein activation, and localization. Adipocyte lipolysis was induced by PCLA treatment via MEK/ERK signaling pathway. These results suggest that the PCLA may prove to be a stable pro-drug to control the deposition of fat in the human body. |
