| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synergistic anti-tumor activity of paclitaxel-incorporated conjugated linoleic acid-coupled poloxamer thermosensitive hydrogel in vitro and in vivo |
| 초록 |
Local delivery of anti-tumor drugs provides a high local concentration and decreases the incidence of side effects commonly observed with systemic therapy. In this study, we prepared a novel thermosensitive conjugated linoleic acid-coupled poloxamer hydrogel for local delivery of paclitaxel. To evaluate the anti-tumor activity of the PTX-incorporated CLA-coupled poloxamer hydrogel in vivo, formulations were injected subcutaneously into tumor-bearing mice. The PTX-incorporated CLA-coupled poloxamer hydrogel showed excellent anti-tumor activity in vivo inducing stronger cell cycle arrest and apoptosis. These results were attributed to the synergistic effect of the anti-tumor property of PTX with released CLA from the CLA-coupled poloxamer and the enhanced solubility of PTX resulting from the micellar property of the CLA-coupled poloxamer. The CLA-coupled poloxamer designed in this study has great potential as an effective injectable carrier of PTX. |
| 저자 |
곽정정1, 허성용1, 전희선1, 송충길1, 김대도1, 최윤재1, 조명행1, 조종수2
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| 소속 |
1서울대, 2농업생명과학대 |
| 키워드 |
hydrogel; poloxamer; conjugated linoleic acid; paclitaxel; thermosensitive
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| E-Mail |
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