| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Chitosan Oligosaccharide/Alginate hydrophilic polyelectrolyte for hydrophobic drugs delivery in Oral therapy systems |
| 초록 |
Oral therapy drug delivery systems are receiving more attention because of the convenience for patients and doctors. However, the orally drug carriers face the burst release at acid medium of stomach, the delivery of hydrophobic drugs are ineffective because of the hydrophilic nature of GIT environment. we introduce the Chitosan Oligosaccharide(COS)/Alginate(Alg) hydrogel for hydrophobic drugs delivery in Oral therapy systems. the dual ionic/covalent crosslinked network was created by Norbornen-functionalized COS (COS-Nb) and Tetrazine-functionalized Alg-Tz; the hydrophobic drug was insitu encapsulated into hydrogels network with Nb/Tz insitu. The hydrophobic drug was successfully encapsulated into hydrophilic matrix with high loading content due to the interaction mechanism of drug molecule and COS-Nb, and the insitu forming of Nb/Tz covalent network. This research opens up the incorporating different types of carbohydrate polymers and applying them to biomedical applications. |
| 저자 |
조이준, Hoang Thi Huong, 이시윤, 임권택
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| 소속 |
부경대 |
| 키워드 |
hydrophobic drugs delivery; Oral therapy; Chitosan Oligosaccharide
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| E-Mail |
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