| 초록 |
Whitening materials cannot easily cross the skin barrier (stratum corneum) to reach melanocytes in the basal layer for inhibiting melanin production. In this study, we aimed to construct a novel ultradeformable liposome using polyglyceryl-3-methylglucose distearate as an edge activator and a hydrogel containing hyaluronic acid and hydroxyethyl cellulose for enhancing whitening activity. The optimized ultradeformable liposome (DL2) contained 10 % edge activator and had a particle size of 78.2 ± 2.7 nm, a zeta potential of -29.9 ± 1.8 mV, a polydispersity index of 0.248, and an entrapment efficiency of 90.7 ± 1.7 %. DL2 enhanced stability and deformability and whitening effect. In addition, DL2 was incorporated into a hydrogel in a dual drug-delivery system and the stability after hydrogel incorporation was evaluated. In Franz cells, the MP-loaded ultradeformable liposome-hydrogel complex showed the highest skin permeation and penetration of MP. |
