| 초록 |
Biocellulose nanofibers (BCNFs) are attractive biomaterials, since they are biocompatible and non-toxic and can be easily chemically modified for a variety of biomedical treatments. Taking advantage of this, herein, we propose a new BCNF-based skin tissue adhesive system for dermal therapy. The essence of our approach is that the BCNFs having involucrin antibody are bound to involucrin in the corneocyte of stratum corneum. The involucrin antibody was coupled with the carboxylic acid of 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized BCNFs by carbodiimide chemistry. Then, the adhesion force between the antibody-conjugated BCNFs and porcine skin was characterized by using the axial rheometer measurement. Finally, we demonstrated that our BCNF bioadhesives exhibited such a strong interaction with skin layer even in wet conditions, thus promising a variety biological applications in the field of dermal therapy. |
