| 초록 |
This study introduces a bacterial cellulose nanofibrils (BCNFs)-based skin adhesive system, which has great potentials for water retention improvement of skin. The essence of our approach is that the BCNFs having bactenecin 7 (Bac7) peptide interacts with cell membrane through hydrophobic and electrostatic interactions. The Bac7 was coupled with the carboxylate of 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized BCNFs to form amide bond. Then, the adhesion force between Bac7-conjugated BCNFs and porcine skin was characterized by using the axial rheometer measurement. Finally, we demonstrated that our skin adhesives exhibited interaction with the skin tissue even under wet conditions, thus promising a variety of biological applications in the field of dermal therapy. |
