| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis of Dendritic PEG and Cell Modification for Anti-fouling Effect |
| 초록 |
Poly(ethylene glycol)(PEG) polymers are well known as anti-fouling materials that are non-toxic, water soluble, chemically stable, and resistant to immune response. To improve anti-fouling effect, dendritic PEGs were synthesized. Dendritic PEGs have samller hydrodynamic volumn and spherical shape compared to linear PEG. Dendritic PEGs were synthesized by living anionic ring opening polymerization of ethylene in THF using diphenylmethyl potassium (DPMK) catalyst. To introduce branch point, allylation and dihydroxylation was carried out. All generations were characterized by 1H NMR spectroscopy and GPC. Focal point and end groups were functionalized for reaction with cell surface and other molecules, respectively. After modification of dendritic PEGs on cell surface, anti-fouling effect was observed. |
| 저자 |
김주은1, 정지헌1, 변영로1, 김정안2, 안철희1
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| 소속 |
1서울대, 2경희대 |
| 키워드 |
PEG; dendritic; anti-fouling
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| E-Mail |
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