| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
분자전자 부문위원회 I |
| 제목 |
Visible Light-Driven Photogeneration of Hydrogen Sulfide (H2S) |
| 초록 |
Hydrogen sulfide (H2S) is an important gasotransmitter. Several photo-induced H2S donors have been developed to date, but their utility is limited due to the requirement of UV light. We have developed a visible light-induced, singlet oxygen-mediated H2S donor. The donor was based on nanoparticles incorporating a 1O2 photosensitizer (IrOMe), a 1O2-responsive H2S donor (DPBS), and a fluorescent H2S probe. Upon photoirradiation, IrOMe converted dioxygen (3O2) into 1O2, which react with DPBS to produce 1,2-diketone and H2S. The H2S photogeneration was also validated by electrochemical measurements using H2S-selctive electrode. Utility of our donor has been demonstrated by switching 1O2 photosensitizer to a visible-light-active PtOEP. The H2S-donating nanoparticles were readily uptaken by HeLa cells. Green LEDs photoirradiation of the treated HeLa cells evoked fluorescence in the cytosol. Finally, we have demonstrated that photogenerated H2S mitigate oxidative stress in HeLa cells. |
| 저자 |
이승연, 문유경, 김신희, 김소남, 박규림, 유영민
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| 소속 |
이화여자대 |
| 키워드 |
Hydrogen sulfide; Visible light induced; H2S donor
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| E-Mail |
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