| 초록 |
Alzheimer’s disease (AD) is a neurodegenerative disease associated with the loss of nerve cell in areas of the brain and lead to cause death sixthly in 2014. Many AD diagnosis studies focus on the blood-based diagnostic test which is easy to obtain the sample and reflects a change of biomarkers from CSF due to the drawbacks of common tests. Among the rich sources in blood, Amyloid beta, Tau protein and 24(s)-hydroxycholesterol, which are closely associated with key mechanism of AD pathology occurring in the brain, are able to be supportive early screening and diagnostic tools. We are developing the multi-detection biosensor of those markers based on Rayleigh scattering and colorimetric assay depended on plasmonic properties of AuNPs. Also, we did pre-treatment with chaotropic agent which interfere the binding between biomarkers and other plasma protein to increase the detection limit. |
